[1]
Ansley, S.J. 2003. Basal Body Dysfunction is a Likely Cause of Pleiotropic Bardet–Biedl Syndrome. Nature. 425, 6958 (2003), 628–633. DOI:https://doi.org/10.1038/nature02030.
[2]
Badano, J.L. 2006. The Ciliopathies: An Emerging Class of Human Genetic Disorders. Annual Review of Genomics and Human Genetics. 7, 1 (2006), 125–148. DOI:https://doi.org/10.1146/annurev.genom.7.080505.115610.
[3]
Bainer, R. and Weaver, V. 2013. Strength Under Tension. Science. 341, 6149 (2013), 965–966. DOI:https://doi.org/10.1126/science.1243643.
[4]
Blundell, T.L. 2000. Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin. Nature. 407, 6807 (2000), 1029–1034. DOI:https://doi.org/10.1038/35039551.
[5]
Bomken, S. 2010. Understanding the Cancer Stem Cell. British Journal of Cancer. 103, 4 (2010). DOI:https://doi.org/10.1038/sj.bjc.6605821.
[6]
Brazil, D.P. 2015. BMP Signalling: Agony and Antagony in the Family. Trends in Cell Biology. 25, 5 (2015), 249–264. DOI:https://doi.org/10.1016/j.tcb.2014.12.004.
[7]
Butterfield, L.H. 2015. Cancer Vaccines. BMJ. 350, (2015), h988–h988. DOI:https://doi.org/10.1136/bmj.h988.
[8]
Cao, J. 2014. Cells Derived From iPSC Can Be Immunogenic — Yes or No? Protein & Cell. 5, 1 (2014), 1–3. DOI:https://doi.org/10.1007/s13238-013-0003-2.
[9]
Chambers, I. and Tomlinson, S.R. 2009. The Transcriptional Foundation of Pluripotency. Development. 136, 14 (2009), 2311–2322. DOI:https://doi.org/10.1242/dev.024398.
[10]
Chen, H.-Z. 2009. Emerging Roles of E2Fs in Cancer: an Exit From Cell Cycle Control. Nature Reviews Cancer. 9, 11 (2009), 785–797. DOI:https://doi.org/10.1038/nrc2696.
[11]
Couzin-Frankel, J. 2015. The Bad Luck of Cancer. Science. 347, 6217 (2015), 12–12. DOI:https://doi.org/10.1126/science.347.6217.12.
[12]
Davis, H. 2014. Aberrant Epithelial GREM1 Expression Initiates Colonic Tumorigenesis from Cells Outside the Stem Cell Niche. Nature Medicine. 21, 1 (2014), 62–70. DOI:https://doi.org/10.1038/nm.3750.
[13]
De Los Angeles, A. 2015. Hallmarks of Pluripotency. Nature. 525, 7570 (2015), 469–478. DOI:https://doi.org/10.1038/nature15515.
[14]
Dynlacht, B. 2007. The E2F Family and Transcriptional Control of the Mammalian Cell Cycle. The Biomedical & Life Sciences Collection. (2007).
[15]
Elenius, K. 1994. Function of the Syndecans - a Family of Cell Surface Proteoglycans. Journal of Cell Science. 107, 11 (1994), 2975–2982.
[16]
Ganem, N.J. 2009. A Mechanism Linking Extra Centrosomes to Chromosomal Instability. Nature. 460, 7252 (2009), 278–282. DOI:https://doi.org/10.1038/nature08136.
[17]
Gao, H. 2012. The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites. Cell. 150, 4 (2012), 764–779. DOI:https://doi.org/10.1016/j.cell.2012.06.035.
[18]
George, J. 2015. Comprehensive Genomic Profiles of Small Cell Lung Cancer. Nature. 524, 7563 (2015), 47–53. DOI:https://doi.org/10.1038/nature14664.
[19]
Greco, V. and Guo, S. 2010. Compartmentalized Organization: a Common and Required Feature of Stem Cell Niches? Development. 137, 10 (2010), 1586–1594. DOI:https://doi.org/10.1242/dev.041103.
[20]
Guilak, F. 2009. Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix. Cell Stem Cell. 5, 1 (2009), 17–26. DOI:https://doi.org/10.1016/j.stem.2009.06.016.
[21]
Guise, T.A. 2013. Breast Cancer Bone Metastases: It’s All about the Neighborhood. Cell. 154, 5 (2013), 957–959. DOI:https://doi.org/10.1016/j.cell.2013.08.020.
[22]
Gupta, G.P. and Massagué, J. 2006. Cancer Metastasis: Building a Framework. Cell. 127, 4 (2006), 679–695. DOI:https://doi.org/10.1016/j.cell.2006.11.001.
[23]
Gupta, G.P. and Massagué, J. 2006. Cancer Metastasis: Building a Framework. Cell. 127, 4 (2006), 679–695. DOI:https://doi.org/10.1016/j.cell.2006.11.001.
[24]
Habedanck, R. 2005. The Polo Kinase Plk4 Functions in Centriole Duplication. Nature Cell Biology. 7, 11 (2005), 1140–1146. DOI:https://doi.org/10.1038/ncb1320.
[25]
Hanahan, D. and Weinberg, R.A. 2011. Hallmarks of Cancer: The Next Generation. Cell. 144, 5 (2011), 646–674. DOI:https://doi.org/10.1016/j.cell.2011.02.013.
[26]
Hanahan, D. and Weinberg, R.A. 2011. Hallmarks of Cancer: The Next Generation. Cell. 144, 5 (2011), 646–674. DOI:https://doi.org/10.1016/j.cell.2011.02.013.
[27]
Hanahan, D. and Weinberg, R.A. 2011. Hallmarks of Cancer: The Next Generation. Cell. 144, 5 (2011), 646–674. DOI:https://doi.org/10.1016/j.cell.2011.02.013.
[28]
Hanahan, D. and Weinberg, R.A. 2000. The Hallmarks of Cancer. Cell. 100, 1 (2000), 57–70. DOI:https://doi.org/10.1016/S0092-8674(00)81683-9.
[29]
Hanahan, D. and Weinberg, R.A. 2000. The Hallmarks of Cancer. Cell. 100, 1 (2000), 57–70. DOI:https://doi.org/10.1016/S0092-8674(00)81683-9.
[30]
Hengartner, M. 2007. Apoptosis in C. Elegans. The Biomedical & Life Sciences Collection. (2007).
[31]
van den Heuvel, S. and Dyson, N.J. 2008. Conserved Functions of the pRB and E2F Families. Nature Reviews Molecular Cell Biology. 9, 9 (2008), 713–724. DOI:https://doi.org/10.1038/nrm2469.
[32]
Hinchcliffe, E.H. 1999. Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts. Science. 283, 5403 (1999), 851–854.
[33]
Hunter, T. 2007. Receptor Tyrosine Kinases - Function, Families and Evolution | The Biomedical & Life Sciences Collection.
[34]
Hynes, R.O. 2002. Integrins:Bidirectional, Allosteric Signaling Machines. Cell. 110, 6 (2002), 673–687. DOI:https://doi.org/10.1016/S0092-8674(02)00971-6.
[35]
Jiang, W. 2012. The Implications of Cancer Stem Cells for Cancer Therapy. International Journal of Molecular Sciences. 13, 12 (2012), 16636–16657. DOI:https://doi.org/10.3390/ijms131216636.
[36]
Kazlauskas, A. 2007. How the PDGF Receptor Induces Cell Proliferation. The Biomedical & Life Sciences Collection. (2007).
[37]
Keklikoglou, I. and De Palma, M. 2014. Cancer: Metastasis Risk After Anti-Macrophage Therapy. Nature. 515, 7525 (2014), 46–47. DOI:https://doi.org/10.1038/nature13931.
[38]
Kleinman, H.K. and Weeks, B.S. 1989. Laminin: Structure, Functions and Receptors. Current Opinion in Cell Biology. 1, 5 (1989), 964–967. DOI:https://doi.org/10.1016/0955-0674(89)90066-5.
[39]
Knoblich, J.A. 2008. Mechanisms of Asymmetric Stem Cell Division. Cell. 132, 4 (2008), 583–597. DOI:https://doi.org/10.1016/j.cell.2008.02.007.
[40]
Krzywicka-Racka, A. 2011. Repeated Cleavage Failure Does Not Establish Centrosome Amplification in Untransformed Human Cells. The Journal of Cell Biology. 194, 2 (2011). DOI:https://doi.org/10.1083/jcb.201101073.
[41]
Lees, J. 2009. The pRB/E2F pathway. The Biomedical & Life Sciences Collection.
[42]
Lemmon, M.A. and Schlessinger, J. 2010. Cell Signaling by Receptor Tyrosine Kinases. Cell. 141, 7 (2010), 1117–1134. DOI:https://doi.org/10.1016/j.cell.2010.06.011.
[43]
Lim, W.A. and Pawson, T. 2010. Phosphotyrosine Signaling: Evolving a New Cellular Communication System. Cell. 142, 5 (2010), 661–667. DOI:https://doi.org/10.1016/j.cell.2010.08.023.
[44]
Lingle, W.L. 2002. Centrosome Amplification Drives Chromosomal Instability in Breast Tumor Development. Proceedings of the National Academy of Sciences of the United States of America. 99, 4 (2002), 1978–1983.
[45]
Lodish, H.F. 2016. Molecular Cell Biology. W.H. Freeman Macmillan Learning.
[46]
Lodish, H.F. 2016. Molecular Cell Biology. W.H. Freeman Macmillan Learning.
[47]
Lodish, H.F. 2016. Molecular Cell Biology. W.H. Freeman Macmillan Learning.
[48]
Lodish, H.F. 2016. Molecular Cell Biology. W.H. Freeman Macmillan Learning.
[49]
Lončarek, J. 2010. Centriole Reduplication During Prolonged Interphase Requires Procentriole Maturation Governed by Plk1. Current Biology. 20, 14 (2010), 1277–1282. DOI:https://doi.org/10.1016/j.cub.2010.05.050.
[50]
Maude, S.L. 2014. Chimeric Antigen Receptor T-cell Therapy for ALL. Hematology. 2014, 1 (2014), 559–564. DOI:https://doi.org/10.1182/asheducation-2014.1.559.
[51]
Meacham, C.E. and Morrison, S.J. 2013. Tumour Heterogeneity and Cancer Cell Plasticity. Nature. 501, 7467 (2013), 328–337. DOI:https://doi.org/10.1038/nature12624.
[52]
Meraldi, P. 2004. Aurora Kinases Link Chromosome Segregation and Cell Division to Cancer Susceptibility. Current Opinion in Genetics & Development. 14, 1 (2004), 29–36. DOI:https://doi.org/10.1016/j.gde.2003.11.006.
[53]
Meraldi, P. 2002. Aurora-A Overexpression Reveals Tetraploidization as a Major Route to Centrosome Amplification in p53-/- Cells. The EMBO Journal. 21, 4 (2002), 483–492. DOI:https://doi.org/10.1093/emboj/21.4.483.
[54]
Morrison, S.J. and Spradling, A.C. 2008. Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life. Cell. 132, 4 (2008), 598–611. DOI:https://doi.org/10.1016/j.cell.2008.01.038.
[55]
Mulloy, B. and Rider, C.C. 2006. Cytokines and Proteoglycans: an Introductory Overview. Biochemical Society Transactions. 34, 3 (2006), 409–413. DOI:https://doi.org/10.1042/BST0340409.
[56]
Naked Mole Rat Wins the War on Cancer | Science | AAAS: 2009. http://www.sciencemag.org/news/2009/10/naked-mole-rat-wins-war-cancer.
[57]
Nguyen, D.X. 2009. Metastasis: from Dissemination to Organ-Specific Colonization. Nature Reviews Cancer. 9, 4 (2009), 274–284. DOI:https://doi.org/10.1038/nrc2622.
[58]
Nigg, E.A. 2002. Centrosome Aberrations: Cause or Consequence of Cancer Progression? Nature Reviews Cancer. 2, 11 (2002), 815–825. DOI:https://doi.org/10.1038/nrc924.
[59]
Nigg, E.A. 1999. Centrosome Duplication in Mammalian Somatic Cells Requires E2F and Cdk2-cyclin A. Nature Cell Biology. 1, 2 (1999), 88–93. DOI:https://doi.org/10.1038/10054.
[60]
Nigg, E.A. and Raff, J.W. 2009. Centrioles, Centrosomes, and Cilia in Health and Disease. Cell. 139, 4 (2009), 663–678. DOI:https://doi.org/10.1016/j.cell.2009.10.036.
[61]
Nigg, E.A. and Raff, J.W. 2009. Centrioles, Centrosomes, and Cilia in Health and Disease. Cell. 139, 4 (2009), 663–678. DOI:https://doi.org/10.1016/j.cell.2009.10.036.
[62]
Nigg, E.A. and Stearns, T. 2011. The Centrosome Cycle: Centriole Biogenesis, Duplication and Inherent Asymmetries. Nature Cell Biology. 13, 10 (2011), 1154–1160. DOI:https://doi.org/10.1038/ncb2345.
[63]
NIH VideoCasting Past Events: https://videocast.nih.gov/pastevents.asp?c=29.
[64]
Nurse, P. 2012. The Richard Dimbleby Lecture 2012: ‘The New Enlightenment’.
[65]
Nybakken, K. and Perrimon, N. 2002. Heparan Sulfate Proteoglycan Modulation of Developmental Signaling in Drosophila. Biochimica et Biophysica Acta (BBA) - General Subjects. 1573, 3 (2002), 280–291. DOI:https://doi.org/10.1016/S0304-4165(02)00395-1.
[66]
Olsen, B.R. 1999. Life without Perlecan Has Its Problems. The Journal of Cell Biology. 147, 5 (1999).
[67]
Oren, M. 2007. p53 and Apoptosis. The Biomedical & Life Sciences Collection. (2007).
[68]
Pazour, G.J. 2000. Chlamydomonas IFT88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg737, Are Required for Assembly of Cilia and Flagella. The Journal of Cell Biology. 151, 3 (2000).
[69]
Pazour, G.J. 2004. Intraflagellar Transport and Cilia-Dependent Renal Disease: The Ciliary Hypothesis of Polycystic Kidney Disease. Journal of the American Society of Nephrology. 15, 10 (2004), 2528–2536. DOI:https://doi.org/10.1097/01.ASN.0000141055.57643.E0.
[70]
Pazour, G.J. 2002. Polycystin-2 Localizes to Kidney Cilia and the Ciliary Level is Elevated in Orpk Mice With Polycystic Kidney Disease. Current Biology. 12, 11 (2002), R378–R380. DOI:https://doi.org/10.1016/S0960-9822(02)00877-1.
[71]
Pazour, G.J. and Rosenbaum, J.L. 2002. Intraflagellar Transport and Cilia-Dependent Diseases. Trends in Cell Biology. 12, 12 (2002), 551–555. DOI:https://doi.org/10.1016/S0962-8924(02)02410-8.
[72]
Pico de Coaña, Y. 2015. Checkpoint Blockade for Cancer Therapy: Revitalizing a Suppressed Immune System. Trends in Molecular Medicine. 21, 8 (2015), 482–491. DOI:https://doi.org/10.1016/j.molmed.2015.05.005.
[73]
Pihan, G.A. et al. 2003. Centrosome Abnormalities and Chromosome Instability Occur Together in Pre-invasive Carcinomas. Cancer Research. 63, (2003).
[74]
Pleasance, E.D. 2010. A Small-Cell Lung Cancer Genome with Complex Signatures of Tobacco Exposure. Nature. 463, 7278 (2010), 184–190. DOI:https://doi.org/10.1038/nature08629.
[75]
Postow, M.A. 2015. Nivolumab and Ipilimumab Versus Ipilimumab in Untreated Melanoma. New England Journal of Medicine. 372, 21 (2015), 2006–2017. DOI:https://doi.org/10.1056/NEJMoa1414428.
[76]
Rezza, A. Adult Stem Cell Niches. Stem Cells in Development and Disease, 107. 333–372.
[77]
Rider, C.C. 2006. Heparin/heparan Sulphate Binding in the TGF-β cytokine Superfamily. Biochemical Society Transactions. 34, 3 (2006), 458–460. DOI:https://doi.org/10.1042/BST0340458.
[78]
Rompolas, P. 2013. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate. Nature. 502, 7472 (2013), 513–518. DOI:https://doi.org/10.1038/nature12602.
[79]
Sanderson, R.D. 2005. Enzymatic Remodeling of Heparan Sulfate Proteoglycans Within the Tumor Microenvironment: Growth Regulation and the Prospect of New Cancer Therapies. Journal of Cellular Biochemistry. 96, 5 (2005), 897–905. DOI:https://doi.org/10.1002/jcb.20602.
[80]
Swift, J. 2013. Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation. Science. 341, 6149 (2013), 1240104–1240104. DOI:https://doi.org/10.1126/science.1240104.
[81]
Tomasetti, C. and Vogelstein, B. 2015. Variation in Cancer Risk Among Tissues Can Be Explained by the Number of Stem Cell Divisions. Science. 347, 6217 (2015), 78–81. DOI:https://doi.org/10.1126/science.1260825.
[82]
Tomasetti, C. and Vogelstein, B. 2015. Variation in Cancer Risk Among Tissues Can Be Explained by the Number of Stem Cell Divisions. Science. 347, 6217 (2015), 78–81. DOI:https://doi.org/10.1126/science.1260825.
[83]
Wang, J. 2006. A Protein Interaction Network for Pluripotency of Embryonic Stem Cells. Nature. 444, 7117 (2006), 364–368. DOI:https://doi.org/10.1038/nature05284.
[84]
Weinberg, R. 2009. Invasion, Metastasis and Stem Cells. The Biomedical & Life Sciences Collection.
[85]
Weinberg, R.A. 2007. ‘The Biology and Genetics of Cells and Organisms’, ‘The Nature of Cancer’ and ‘Tumor Viruses’. The Biology of Cancer. Garland Science. 1–103.
[86]
Weinberg, R.A. 2014. The Biology of Cancer. Garland Science.
[87]
Weinberg, R.A. 2014. The Biology of Cancer. Garland Science.
[88]
Weinberg, R.A. 2014. The Biology of Cancer. Garland Science.
[89]
Weinberg, R.A. 2014. The Biology of Cancer. Garland Science.
[90]
Weinberg, R.A. 2014. The Biology of Cancer. Garland Science.
[91]
Weinberg, R.A. 2014. The Biology of Cancer. Garland Science.
[92]
Weinberg, R.A. 2014. The Biology of Cancer. Garland Science.
[93]
Wodarz, D. and Zauber, A.G. 2015. Cancer: Risk Factors and Random Chances. Nature. 517, 7536 (2015), 563–564. DOI:https://doi.org/10.1038/517563a.
[94]
Wu, S. 2015. Substantial Contribution of Extrinsic Risk Factors to Cancer Development. Nature. 529, 7584 (2015), 43–47. DOI:https://doi.org/10.1038/nature16166.
[95]
Yamada, K.M. 1989. Fibronectins: Structure, Functions and Receptors. Current Opinion in Cell Biology. 1, 5 (1989), 956–963.
[96]
Yu, Z. 2012. Cancer Stem Cells. The International Journal of Biochemistry & Cell Biology. 44, 12 (2012), 2144–2151. DOI:https://doi.org/10.1016/j.biocel.2012.08.022.
[97]
Zhang, X.H.-F. 2013. Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma. Cell. 154, 5 (2013), 1060–1073. DOI:https://doi.org/10.1016/j.cell.2013.07.036.
[98]
Zhao, T. 2015. Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. Cell Stem Cell. 17, 3 (2015), 353–359. DOI:https://doi.org/10.1016/j.stem.2015.07.021.
[99]
Zhou, Q. 2007. A Gene Regulatory Network in Mouse Embryonic Stem Cells. Proceedings of the National Academy of Sciences of the United States of America. 104, 42 (2007), 16438–16443.