globe
  1. Essential Course Readings 2 items
    1. Molecular Cell Biology - Harvey F. Lodish 2016

      Book Essential

    2. The Cell Cycle: Principles of Control - David O Morgan 2007

      Book Essential

  2. Journals and Online Lectures 6 items
    1. This will be supplemented by short reviews from journals such as Current Biology, Current Opinion in Cell Biology, Nature Reviews and Trends in Cell Biology and online lectures, such the the HS talks.

  3. Selected Papers 6 items
    The aim of this exercise is to develop skills to be able to read, understand and discuss primary research papers. Students will be provided research papers on the topics of 1. cell cycle control, 2. DNA synthesis and 3. mitosis.
    1. CDK Substrate Phosphorylation and Ordering the Cell Cycle - Matthew P. Swaffer, Andrew W. Jones, Helen R. Flynn, Ambrosius P. Snijders 2016

      Article Recommended

    2. Regulated Eukaryotic DNA Replication Origin Firing With Purified Proteins - Joseph T. P. Yeeles, Tom D. Deegan, Agnieszka Janska, Anne Early 2015

      Article Recommended

    3. Chromatin Shapes the Mitotic Spindle - Ana Dinarina, Céline Pugieux, Maria Mora Corral, Martin Loose 2009

      Article Recommended

    4. A Contractile Nuclear Actin Network Drives Chromosome Congression in Oocytes - Péter Lénárt, Christian P. Bacher, Nathalie Daigle, Arthur R. Hand 2005

      Article Recommended

    5. Distinct Mechanisms Eliminate Mother and Daughter Centrioles in Meiosis of Starfish Oocytes - Joana Borrego-Pinto, Kálmán Somogyi, Matthia A. Karreman, Julia König 2016

      Article Recommended

  4. Basic Cell Cycle Regulatory Mechanisms 11 items
    1. Talks to Watch 4 items
      1. The Great Ideas of Biology - Paul Nurse 2013

        Audio-visual document Recommended

      2. START Control in Yeast - Curt Wittenberg 2009

        Article Recommended

      3. The G2/M Transition - René Medema 2009

        Article Recommended

    2. Papers to Read 4 items
      1. Network Dynamics and Cell Physiology - John J. Tyson, Kathy Chen, Bela Novak 2001

        Article Recommended

      2. Temporal Organization of the Cell Cycle - John J. Tyson, Bela Novak 2008

        Article Recommended

      3. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapters 1, 2 and 3

      4. Driving the Cell Cycle With a Minimal Cdk Control Network - Damien Coudreuse, Paul Nurse 2010

        Article Recommended Overview of this study on Moodle

    3. Flow Cytometry Reading 3 items
      1. Flow Cytometers - John A. Steinkamp

        Chapter Recommended

      2. Cell Cycle: Synchronization at Various Stages - Sharon Tate, Paul Ko Ferrigno

        Chapter Recommended

  5. Cell Biology and Imaging Techniques 1 item
    1. No readings listed

  6. Fluorescence Microscopy, Live Cell Imaging, GFP, FRAP, FRET. 1 item
    1. No readings listed

  7. Organelle Biology, Mitochondria, Chloroplasts 5 items
    1. Papers to Read 1 item
      1. Ancient Invasions: From Endosymbionts to Organelles - Sabrina D Dyall, Mark T Brown, Patricia J Johnson 2004

        Article Further

    2. Talks to Watch 2 items
      1. The Origin of Eukaryotes - Neil Blackstone 2016

        Article Recommended

    3. Practical 2 items
      1. The Making of a Chloroplast - Mark T Waters, Jane A Langdale 2009

        Article Further

  8. Regulation of S-phase, S-phase checkpoints. 3 items
    1. Talks to Watch 1 item
      1. Replication Licensing - Julian Blow 2009

        Audio-visual document Recommended

    2. Papers to Read 2 items
      1. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapter 4: Chromosome Duplication

      2. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapter 11: The DNA Damage Response

  9. Cell Motility 1 item
    1. Molecular Cell Biology - Harvey F. Lodish 2016

      Book Recommended Chapter 19 of Lodish et al., Molecular Cell Biology is sufficient to understand this topic at this level. Indeed, it contains far more information that I cover but it reads well so will be a good introduction to the topic.

  10. Vesicle Trafficking 1 item
    1. Molecular Cell Biology - Harvey F. Lodish 2016

      Book Recommended The Golgi and vesicle trafficking are covered well in Lodish et al., chapter 14.

  11. Regulation of Mitosis and Meiosis, Mitotic Checkpoints 7 items
    1. Talks to Watch 2 items
      1. Bipolar Spindle Assembly - Eric Karsenti 2009

        Audio-visual document Recommended

    2. Papers to Read 5 items
      1. Meiosis: Cell-Cycle Controls Shuffle and Deal - Adèle L. Marston, Angelika Amon 2004

        Article Recommended

      2. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapter 5: Early Mitosis- Preparing the Chromosomes for Segregation

      3. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapter 6: Assembly of the Mitotic Spindle.

      4. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapter 9: Meiosis

  12. Entry Into Cell Proliferation 4 items
    1. Talks to Watch 1 item
    2. Papers to Read 3 items
      1. Conserved Functions of the pRB and E2F Families - Sander van den Heuvel, Nicholas J. Dyson 2008

        Article Recommended

      2. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapter 10: Control of Cell Proliferation and Growth.

      3. The Cell Cycle: Principles of Control - David O Morgan 2007

        Book Recommended Chapter 12: The Cell Cycle in Cancer.

  13. Cell Cycle and Development 4 items
    1. Papers to Read 4 items
      1. A Journey Into Space - Jacqueline Hayles, Paul Nurse 2001

        Article Recommended

All rights reserved ©