globe
  1. Key Bibliography 8 items
    1. An Introduction to Molecular Ecology - Graham Rowe, Michael Sweet, Trevor J. C. Beebee 2017

      Book Essential

    2. Genomes 3 - T. A Brown 2007

      Book Essential Old edition, but most of the chapters on this list refer to this edition.

    3. Genomes 4 - T. A. Brown 2018

      Book Essential Newest edition

    4. An Introduction to Genetic Engineering - Desmond S. T. Nicholl 2008

      Book Recommended

    5. An Introduction to Genetic Engineering - Desmond S. T. Nicholl 2008 (electronic resource)

      Book Recommended

    6. Principles of Gene Manipulation and Genomics - S. B. Primrose, Richard M. Twyman 2006

      Book Recommended

    7. Principles of Gene Manipulation and Genomics - Sandy B. Primrose, Richard Twyman 2009 (electronic resource)

      Book Recommended

    8. Human Molecular Genetics - T. Strachan, Andrew P. Read, Tom Strachan 2011

      Book Essential

  2. Lectures 3 & 4 13 items
    1. Literature and Further Readings 13 items
      1. ·         DNA sequencing

         

        ·         Next generation sequencing: methods and applications

      2. Useful Websites 4 items
  3. Lectures 5 & 6 6 items
    1. ·         The use of genetic engineering in agriculture

       

      ·         Methods and rationale for the genetic modification of commodity crops

    2. International Service for the Acquisition of Agri-biotech Applications - ISAAA.org

      Website Essential An up to date newsletter on the latest developments in plant biotech, especially GM crops. Worth following throughout the year. It includes links to many of the examples given in the lectures. You can subscribe, if you wish.

    3. Cisgenic Plants Are Similar to Traditionally Bred Plants: International Regulations for Genetically Modified Organisms Should Be Altered to Exempt Cisgenesis - Henk J. Schouten, Frans A. Krens, Evert Jacobsen 2006

      Article Essential This paper clovers cis genesis, as discussed in these lectures.

    4. Cisgenesis and Intragenesis: New Tools for Improving Crops - C. Espinoza, R. Schlechter, D. Herrera, E. Torres 2013

      Article Essential Another article on cis genesis from 2013

    5. Role of Transgenic Plants in Agriculture and Biopharming - Parvaiz Ahmad, Muhammad Ashraf, Muhammad Younis, Xiangyang Hu 2012

      Article Essential

  4. Lectures 7 & 8 12 items
      • Crop improvement by genetic modification: economics, examples and debate

    1. Alpha & Omega: Making Omega-3 Fish Oils in GM Camelina Plants - Johnathan Napier, Douglas Tocher

      Webpage Essential Details of the work on GM Camelina to produce omego-3 oils, using genes from algae to produce omega-3 fish oils.

    2. A Meta-Analysis of the Impacts of Genetically Modified Crops - Wilhelm Klümper, Matin Qaim 2014

      Article Essential A meta analysis of the impacts of GM crops. The conclusion from this study is that GM crops benefit farmers in developed and developing countries.

    3. The Golden Rice Project

      Website Essential The web site for Golden Rice, including the scientific strategy, the history of the project and all the latest developments.

    4. Case Studies: A Hard Look at GM Crops - Natasha Gilbert 2013

      Article Essential A 'hard look', to quote the author, at GM crops, published in Nature.

    5. Groups Opposing GM Crops 6 items
      There are many groups that oppose the commercialisation of GM crops and foods and voice their concerns regularly. They usually have web sites, and include:
      1. Greenpeace UK

        Website Essential Search or GM crops on the home page.

      2. Anti-GMO Groups - United States | GMO Awareness

        Webpage Essential A US-based group. The site includes a list of anti-GMO groups worldwide.

  5. Lectures 9 & 10: 12 items
    1. Problem based learning activity - Glyphosate-tolerant crops

    2. Thompson & Thompson Genetics in Medicine - Robert L. Nussbaum, Roderick R. McInnes, Huntington F. Willard 2016

      Book Essential The electronic copy of the book Genetics in Medicine is now available for you. The chapters I suggest are 4 (Diversity: mutation and polymorphism); Chapter 8 (multifactorial disorders; examples of multifactorial diseases); Chapter 10 (from GWAS): Chapter 18 (applications of genomics to medicine, from pharmacogenomics).

    3. Thompson & Thompson Genetics in Medicine - Robert L. Nussbaum, Roderick R. McInnes, Huntington F. Willard (electronic book)

      Book Essential The electronic copy of the book Genetics in Medicine is now available for you. The chapters I suggest are 4 (Diversity: mutation and polymorphism); Chapter 8 (multifactorial disorders; examples of multifactorial diseases); Chapter 10 (from GWAS): Chapter 18 (applications of genomics to medicine, from pharmacogenomics).

    4. Selected Suggested Literature 8 items
      1. Metagenomic Exploration of Viruses Throughout the Indian Ocean - Shannon J. Williamson, Lisa Zeigler Allen, Hernan A. Lorenzi, Douglas W. Fadrosh 2012

        Article Recommended

      2. What Are Genome-Wide Association Studies? - Genetics Home Reference

        Webpage Recommended After reading the website, follow the link: “a detailed explanation of genome wide association studies”

  6. Lectures 11 & 12: 18 items
    1. ·         Using sequence data to study mitochondrial and early eukaryotic evolution

    2. Molecular Phylogenetics - T. A. Brown 2007

      Chapter Recommended This chapter is only in Genomes 3 (not in Genomes 4)

    3. RNA-Seq: a revolutionary tool for transcriptomics - Zhong Wang, Mark Gerstein, Michael Snyder 2009-1

      Article Recommended

    4. Protein Import, Replication, and Inheritance of a Vestigial Mitochondrion - Attila Regoes, Danai Zourmpanou, Gloria León-Avila, Mark van der Giezen 26/08/2005

      Article Recommended

    5. Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes - Michelle M. Leger, Martin Kolisko, Ryoma Kamikawa, Courtney W. Stairs 2017-3-13

      Article Recommended

    6. Integrated genomic and fossil evidence illuminates life’s early evolution and eukaryote origin - Holly C. Betts, Mark N. Puttick, James W. Clark, Tom A. Williams 10/2018

      Article Further

    7. The Minimal Proteome in the Reduced Mitochondrion of the Parasitic Protist Giardia intestinalis - Petr L. Jedelský, Pavel Doležal, Petr Rada, Jan Pyrih 2011-2-24

      Article Further

    8. Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum - Luboš Voleman, Vladimíra Najdrová, Ásgeir Ástvaldsson, Pavla Tůmová 12/2017

      Article Further

    9. Mutation Rates - Graham Rowe, Michael Sweet, Trevor Beebee 2017

      Chapter Essential

    10. mtDNA and rRNA - Graham Rowe, Michael Sweet, Trecor Sweet 2017

      Chapter Essential

    11. Microsatellites - Graham Rowe, Michael Sweet, Trevor Beebee 2017

      Chapter Essential

    12. Replication Slippage - T. A. Brown 2007

      Chapter Essential

    13. Identifying relatives in Behavioural Ecology - Graham Rowe, Michael Sweet, Trevor Beebee 2017

      Chapter Essential

    14. Nest Inheritance Is the Missing Source of Direct Fitness in a Primitively Eusocial Insect - E. Leadbeater, J. M. Carruthers, J. P. Green, N. S. Rosser 2011

      Article Essential

    15. Assignment Tests - Graham Rowe, Michael Sweet, Trevor Beebee 2017

      Chapter Essential

    16. DNA Profiling - Alan Gunn 2008

      Chapter Essential

  7. Lectures 13 & 14 15 items
    1. ·         Molecular identification of species

       

      ·         Transcriptomics

    2. Essential Reading 3 items
      1. Microarrays - T. A. Brown 2007

        Chapter Essential

      2. Other papers referenced in slides: these are essential reading!

    3. Recommended Reading 11 items
      1. Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus - Jorge Tovar, Shane Wilkinson, Jeremy C. Mottram, Alan H. Fairlamb 07/1998

        Article Recommended

      2. Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress - S. Krieger, W. Schwarz, M. R. Ariyanayagam, A. H. Fairlamb 05/04/2002

        Article 

      3. Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects - Nathaniel G. Jones, Carolina M. C. Catta-Preta, Ana Paula C. A. Lima, Jeremy C. Mottram 2018

        Article 

      4. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach - Megan H. Wright, Barbara Clough, Mark D. Rackham, Kaveri Rangachari 2014-2

        Article Recommended

      5. RNA-seq: A Revolutionary Tool for Transcriptomics - Zhong Wang, Mark Gerstein, Michael Snyder 2009

        Article Recommended

      6. Dna Barcoding - Graham Rowe, Michael Sweet, Trevor Beebee 2017

        Chapter Essential

      7. Prey ID - Graham Rowe, Michael Sweet, Trevor Beebee 2017

        Chapter Recommended

      8. Predators and Prey - Joanna R. Freeland, Heather Kirk, Stephen Petersen 2011

        Chapter Recommended

      9. Predators and Prey - Joanna R. Freeland, Heather Kirk, Stephen Petersen 2011

        Chapter Recommended

  8. Lectures 15 & 16 10 items
    1. ·         Human inherited disease 

       

      ·         Human gene therapy

    2. Further Reading 9 items
      1. Genetic Mapping of Mendelian Characters - T. Strachan, Andrew P. Read, Tom Strachan 2011

        Chapter Further

      2. Mapping Genes Conferring Susceptibility to Complex Diseases - T. Strachan, Andrew P. Read, Tom Strachan 2011

        Chapter Further

      3. Identifying Human Disease Genes and Susceptibility Factors - T. Strachan, Andrew P. Read, Tom Strachan 2011

        Chapter Further

      4. Genetic Approaches to Treating Disease - T. Strachan, Andrew P. Read, Tom Strachan 2011

        Chapter Further

      5. Restoring Dystrophin Expression in Duchenne Muscular Dystrophy Muscle - Eric P. Hoffman, Abby Bronson, Arthur A. Levin, Shin'ichi Takeda 2011

        Article Further

  9. Lectures 17 & 18 1 item
    1. ·         Human inherited disease and human gene therapy

       

      ·         Molecular vaccinology

  10. Lectures 18-20 Molecular Vaccinology 11 items
    1. If you read nothing else, read this: 1 item
      1. Immunology - Thomas J Kindt, Barbara Anne Osborne, Richard A Goldsby, Janis Kuby 2007

        Book Essential Read chapter 19 on vaccines.

    2. Another useful overview review: 1 item
      1. Vaccination: The Present and the Future - Saheli Sadanand 2011

        Webpage Recommended Please check Moodle

    3. Lecture 1 2 items
    4. Lecture 2 2 items
      1. High throughput technologies: 1 item
        1. FEBS letters 2006 (pdf on Moodle, relevant sections highlighted)

    5. Lecture 3 5 items
      1. Plant Vaccines: 1 item
        1. Plant-Made Vaccine Antigens and Biopharmaceuticals - Henry Daniell, Nameirakpam D. Singh, Hugh Mason, Stephen J. Streatfield 2009

          Article Essential

      2. Virus Vectors: 1 item
        1. Viruses - From Pathogens to Vaccine Carriers - Juliana C. Small, Hildegund C. J. Ertl 2011

          Article Essential pdf on moodle, relevant sections highlighted.

  11. Lecture 19 & 20: Molecular Vaccinology 3 items
    1. Post-Genomic Vaccine Development - Davide Serruto, Rino Rappuoli 2006

      Article Essential

    2. Plant-Made Vaccine Antigens and Biopharmaceuticals - Henry Daniell, Nameirakpam D. Singh, Hugh Mason, Stephen J. Streatfield 2009

      Article Essential

    3. Viruses From Pathogens to Vaccine Carriers - Juliana C. Small, Hildegund C. J. Ertl 2011

      Article Essential

All rights reserved ©